HIV-1 inhibitor 18A( Compound 18A )

Catalog No. M14111 CAS No. 331261-50-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

HIV-1 inhibitor 18A
Note

Research use only, not for human use.
Brief Description

HIV-1 inhibitor 18A is a novel broad HIV-1 inhibitor that blocks envelope glycoprotein transitions critical for entry.
Description

HIV-1 inhibitor 18A is a novel broad HIV-1 inhibitor that blocks envelope glycoprotein transitions critical for entry, specifically inhibits the entry of a wide range of HIV-1 isolates with mean IC50 of 6.4 uM; inhibits the CD4-induced disruption of quaternary structures at the trimer apex and the exposure of the gp41 HR1 coiled coil, does not interfere with CD4 or CCR5 binding.
In Vitro

Cell Viability Assay Cell Line:PBMCs Concentration:0.01-10 μM Incubation Time:40-44 h Result:Inhibited infection of HIV-1JR-FL, with an IC50 value of 0.4 μM.
In Vivo

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Synonyms

Compound 18A
Pathway

Microbiology/Virology
Target

HIV
Recptor

HIV
Research Area

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Indication

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CAS Number

331261-50-8
Formula Weight

313.33
Molecular Formula

C14H11N5O2S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(N/N=C/C1=CC=C(O)C=C1)NC2=CC=CC3=NSN=C32
Chemical Name

N-2,1,3-Benzothiadiazol-4-yl-2-[(4-hydroxyphenyl)methylene]-hydrazinecarboxamide

1. Herschhorn A, et al. Nat Chem Biol. 2014 Oct;10(10):845-52. 2. Berinyuy E, et al. J Recept Signal Transduct Res. 2016;36(2):119-29.

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